Work

An Evolutionary View of the Arms Race between Protein Kinase R and Large DNA Viruses

Year: 2016

Type: review

Abstract: To establish productive infections, viruses must counteract numerous cellular defenses that are poised to recognize viruses as nonself and to activate antiviral pathways. The opposing goals of host and viral factors lead to evolutionary arms races that can be illuminated by evolutionary and computational methods and tested in experimental models. Here we illustrate how this perspective has been contributing to our understanding of the interactions of the protein kinase R pathway with large DNA viruses.

Source: Journal of Virology

DOI: 10.1128/jvi.01996-15

Authors: Kathryn S. Carpentier, Adam P. Geballe

Institutions: University of Washington, Fred Hutch Cancer Center

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development