Periodontal Ligament and Alveolar Bone in Health and Adaptation: Tooth Movement
Year: 2015
Type: book-chapter
Abstract: The periodontal ligament (PDL) and alveolar bone are two critical tissues for understanding orthodontic tooth movement. The current literature is replete with descriptive studies of multiple cell types and their matrices in the PDL and alveolar bone, but is deficient with how stem/progenitor cells differentiate into PDL and alveolar bone cells. Can one type of orthodontic force with a specific magnitude and frequency activate osteoblasts, whereas another force type activates osteoclasts? This chapter will discuss the biology of not only mature cells and their matrices in the periodontal ligament and alveolar bone, but also stem/progenitor cells that differentiate into fibroblasts, osteoblasts and osteoclasts. Key advances in tooth movement rely on further understanding of osteoblast and fibroblast differentiation from mesenchymal stem/progenitor cells, and osteoclastogenesis from the hematopoietic/monocyte lineage.
DOI: 10.1159/000351894
Authors: Nan Jiang, Weihua Guo, Mo Chen, Ying Zheng, Jian Zhou, Sahng Gyoon Kim, Mildred C. Embree, Karen Songhee Song, Heloisa F. Marao, Jeremy J. Mao
Institution: Columbia University Irving Medical Center
Language: English
Subfield: Orthodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: green
Awards: Engineering of Vascularized Bone, G3038389722, ENGINEERING CRANIOFACIAL OSTEOGENESIS--MECHANICAL FORCES, Tracking stem cells in engineered tissue and organs in vivo and in real time, Multidisciplinary Training in TMJ Disorders/Pain: Integrating Basic, Translation, Regeneration of Clinically Relevant Orofacial Tissues in Pre-Clinical Models
OpenAlex ID: W2274037194