Year: 2016
Type: review
Abstract: Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures. The first indication of how G-quadruplex structures could be unfolded enzymatically came in the late 1990s with reports that some well-known duplex DNA helicases resolved these structures in vitro. Since then, the number of studies reporting G-quadruplex DNA unfolding by helicase enzymes has rapidly increased. The present review aims to present a general overview of the helicase/G-quadruplex field.
Source: Nucleic Acids Research
DOI: 10.1093/nar/gkw079
Institutions: Centre National de la Recherche Scientifique, Université de Bordeaux, Inserm, Institut Européen de Chimie et Biologie, Acides nucléiques: Régulations naturelles et artificielles, Sorbonne Université, Structure et Instabilité des Génomes, National Institutes of Health, National Institute on Aging
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,992
OpenAlex ID: W2275411324