The relationship between birth weight, insulin resistance and glucose intolerance in 7-year old black children
Year: 2009
Type: dissertation
Study design: Observational Study
Abstract: We investigated the relationship between glucose tolerance and birth weight in a group \nof 7-year-old black South Africans on whom longitudinal anthropometric data were \navailable. Oral glucose tolerance tests (OGTT’s) were carried out on 152 subjects and \ninverse correlations were found between birth weight and the total amount of insulin \nsecreted during the first 30 minutes (r= -0.19, p=0.04) and the last 90 minutes (r= -0.19, \np=0.04) of the oral glucose tolerance test and also between birth weight and the 30 minute \nglucose concentrations (r= -0.20, p=0.02). Children born with low birth weights but who \nhad high weights at 7 years, had higher insulin concentrations and indices of obesity \ncompared with those with low birth weights and low weights at 7 years of age. There were \nalso positive correlations between weight velocity and BMI (r=0.24, p=0.02) and weight \nvelocity and postprandial insulin levels (r=0.31, p=0.001). Thus low birth weight in \nconjunction with rapid childhood gains in weight especially as subcutaneous fat, produces \npoor glucose tolerance in 7-year-old children and may make them susceptible to the \ndevelopment of Type II diabetes later in life.
Author: J. Trusler
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Medical Research Council
OpenAlex ID: W2275435769