Work

Oxygen tension, H2S, and NO bioavailability: is there an interaction?

Year: 2015

Type: article

Abstract: Molecular oxygen (O2) is an essential component for survival and development. Variation in O2 levels leads to changes in molecular signaling and ultimately affects the physiological functions of many organisms. Nitric oxide (NO) and hydrogen sulfide (H2S) are two gaseous cellular signaling molecules that play key roles in several physiological functions involved in maintaining vascular homeostasis including vasodilation, anti-inflammation, and vascular growth. Apart from the aforementioned functions, NO and H2S are believed to mediate hypoxic responses and serve as O2 chemosensors in biological systems. In this literature review, we briefly discuss NO and H2S and their roles during hypoxia.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00365.2015

Authors: Gopi K. Kolluru, Priya K. Prasai, Amir M. Kaskas, Vijay Letchuman, Christopher B. Pattillo

Institution: Louisiana State University Health Sciences Center Shreveport

Language: English

Topic: Sulfur Compounds in Biology

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: American Heart Association

Award: Influence of Glutathione on Ischemic Angiogenesis