Is misoprostol teratogenic? Misoprostol use during early pregnancy and its association with Möbius' syndrome.
Year: 1999
Type: article
Study design: Observational Study
Abstract: This retrospective case-control study examined the association between the unsuccessful use of abortifacient misoprostol during the first trimester of pregnancy and Mobius syndrome in the infant. This study compared 96 infants with Mobius syndrome (cases) with 96 infants with neural tube defects (controls). The study was conducted in Brazil by the Motherisk Program at the Hospital for Sick Children of Toronto Ontario. Findings demonstrated that almost half (49%) of the mothers with Mobius syndrome infants had used misoprostol during their first trimester compared with 3% of the mothers with neural tube defect infants. Several of the mothers (20/47) had taken misoprostol orally; 20 had used it both orally and vaginally. Comparison of the baseline characteristic showed that mothers of infants with neural tube defects had low-birth-weight babies and were delivered through cesarean section. Both groups were statistically the same in educational level gravidity parity number of previous miscarriages and induced abortions rate of consanguinity use of alcohol and cigarettes and presence or absence of hyperthermia in the first trimester. The study suggests a strong association between unsupervised unsuccessful use of misoprostol for attempted abortion and Mobius syndrome in the infant.
Source: PubMed Central
Author: K Pottie
Institutions: York University, York University, University of York
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2276004141