Work

Disseminated tumor cells and dormancy in prostate cancer metastasis

Year: 2016

Type: review

Abstract: It has been reported that disseminated tumor cells (DTCs) can be found in the majority of prostate cancer (PCa) patients, even at the time of primary treatment with no clinical evidence of metastatic disease. This suggests that these cells escaped the primary tumor early in the disease and exist in a dormant state in distant organs until they develop in some patients as overt metastases. Understanding the mechanisms by which cancer cells exit the primary tumor, survive the circulation, settle in a distant organ, and exist in a quiescent state is critical to understanding tumorigenesis, developing new prognostic assays, and designing new therapeutic modalities to prevent and treat clinical metastases.

Source: Current Opinion in Biotechnology

DOI: 10.1016/j.copbio.2016.02.002

Authors: Emma E van der Toom, James E Verdone, Kenneth J Pienta

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital, Vrije Universiteit Amsterdam

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,530