Work

Adenoviral-delivered HE4-HSV-tk sensitizes ovarian cancer cells to ganciclovir.

Year: 2013

Type: article

Abstract: to 23.9 μg/mL and 32.6 μg/mL in A2780-CS and -CR, respectively, at 1000 multiplicity of infection. The results support the potential use of this approach as a gene therapy for OC, a disease that accounts for more deaths than any other cancer of the female reproductive system.

Source: PubMed

Authors: Jennifer W Rawlinson, Kiara Vaden, Joseph Hunsaker, David F Miller, Kenneth P Nephew

Institutions: Indiana University Bloomington, Brigham Young University - Idaho, Indiana University School of Medicine, Indiana University, Indiana University Melvin and Bren Simon Comprehensive Cancer Center

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, National Center for Research Resources

Awards: Idaho INBRE Program, Interrogating Epigenetic Changes in Cancer Genomes, Idaho INBRE Program