Work

Synthesis and Utility of Dihydropyridine Boronic Esters

Year: 2015

Type: article

Abstract: When activated by an acylating agent, pyridine boronic esters react with organometallic reagents to form a dihydropyridine boronic ester. This intermediate allows access to a number of valuable substituted pyridine, dihydropyridine, and piperidine products.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201510027

Authors: Santanu Panda, Aaron Coffin, Q. Nhu Nguyen, Dean J. Tantillo, Joseph M. Ready

Institutions: The University of Texas Southwestern Medical Center, University of California, Davis

Language: English

Topic: Organoboron and organosilicon chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, National Institute of General Medical Sciences

Awards: G2610524329, Synthesis and Evaluation of Biologically Active Natural Products