Chronic pancreatitis and pancreatic cancer; the clinical aspects and treatment of pancreatic exocrine insufficiency
Year: 2013
Type: dissertation
Abstract: In exocrine pancreatic insufficiency, the pancreas is unable to deliver a sufficient quantity of \npancreatic enzymes to the small intestine to digest food. It may occur in several life threatening \ndiseases, including chronic pancreatitis and pancreatic cancer. Due to this lack or absence of \npancreatic enzymes, malabsorption of fat develops, which causes steatorrhea-related symptoms, \nweight loss, and malnutrition. To reduce morbidity and even mortality, patients should \nbe treated with a sufficient amount of oral pancreatic enzymes. \nIn clinical practice, enzyme supplementation therapy seems to be a challenge, because the \noptimal enzyme dose is highly variable, depending on the remaining pancreatic function, \nthe postsurgical anatomy, and dietary fat content. Unfortunately, this seems to be an underexposed \ntopic (as the literature overview in chapter 2 shows), and physicians are often not well
Author: Edmée C.M. Sikkens
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2278976545