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The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer

Year: 2004
Type: article
Abstract: Aurora-2 is a serine threonine kinase that associates with the centrosome. Overexpression or ectopic expression of Aurora-2 appears to alter centrosome number and function and has been implicated in a variety of human cancers. In this work, we demonstrate that Aurora-2 is both amplified and overexpressed in human pancreatic cancer cell lines, with a 2-5-fold increase in gene copy number and a 3-4-fold increase in protein levels compared with controls. Aurora-2 is also amplified and overexpressed in pancreatic cancers taken directly from patients. An immunohistochemistry of tissues taken directly from patients demonstrated an overexpression of Aurora-2 in 26 of 28 pancreatic cancers compared with 18 normal pancreas samples. Antisense nucleotides specifically targeted at Aurora-2 arrest the cell cycle in pancreatic cancer cells, indicating the potential of Aurora-2 as a therapeutic target in pancreatic cancer.
DOI: 10.1158/1535-7163.451.3.4
Authors: Sangeeta Rojanala, Haiyong Han, Rubén M. Muñoz, Walden Browne, Raymond Nagle, Daniel D. Von Hoff, David J. Bearss
Language: English
Subfield: Cell Biology
Open Access status: bronze
Awards: G127339028, Aurora Kinases as Therapeutic Targets in Pancreatic Cancer, NOVEL APPROACHES TO ANTITUMOR DRUG DESIGN, G7603411650, University of Arizona Cancer Center - Cancer Center Support Grant, G903185969
OpenAlex ID: W2279017153
FWCI: 2.801
Cites: 24
Cited by: 78
Related to: 10