The immunological response to breast implant: the role of cells and cytokines in the periprosthetic capsule and their involvement in the onset of the autoimmune diseases
Year: 2013
Type: dissertation
Abstract: Since their discovery breast prostheses have been criticized for being responsible for triggering systemic autoimmune disease. The presence of breast implants causes a natural foreign body reaction characterized by the infiltration of macrophages and T-cells. In order to understand which immunological pathways could be responsible for giving rise to, and the development of, connective tissue disease such as systemic sclerosis, I considered the cells and cytokines involved, focusing on the relationship between tissue growth factor-β, interleukin (IL)-1, IL-6 and T helper 17 and/or T regulatory cells, and their effects on the different steps of capsular tissue formation. A disturbance in the modulation of these key cytokines may be responsible, in susceptible individuals, for a perpetuation of the inflammatory reaction which can locally lead to capsular contracture and at the systemic level may contribute to triggering autoimmune diseases
Author: Carlotta Scarpa
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2279211039