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Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

Year: 2016

Type: article

Abstract: Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes. This review highlights various methods for the synthesis of glycoconjugates and recent progress in the development of glycosylated peptide therapeutics. Furthermore, the impacts of glycosylation in overcoming the existing barriers that restrict oral and brain delivery of peptides are described herein.

Source: Chemical Science

DOI: 10.1039/c5sc04392a

Authors: Shayli Varasteh Moradi, Waleed M. Hussein, Pegah Varamini, Pavla Simerska, Istvan Toth

Institutions: The University of Queensland, Institute for Molecular Bioscience

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: University of Queensland, Medical Research Council, Australian Research Council, National Health and Medical Research Council