Work

Paracrine WNT5A signaling in healthy and neoplastic mammary tissue

Year: 2015

Type: article

Abstract: Paracrine signaling between mammary epithelial cells has long been appreciated. Recently, we found that Wnt5a, a novel noncanonical Wnt ligand of luminal origin, counteracts canonical Wnt signaling in basal mammary epithelial cells through a paracrine pathway, inhibits the expansion of Erbb2-induced tumor-initiating cells, and suppresses tumor incidence and metastasis.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2015.1040145

Authors: David Kusner, Nicholas Borcherding, Weizhou Zhang

Institutions: University of Iowa, University of Iowa Holden Comprehensive Cancer Center

Language: English

Topic: Wnt/β-catenin signaling in development and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze