Work

The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy

Year: 2016

Type: article

Abstract: a sequential C-H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C-H arylations, a copper-catalysed C-H amination and a palladium-catalysed C-H carbonylation, which build up the structural complexity of the natural product framework.

Source: Chemical Science

DOI: 10.1039/c5sc04399a

Authors: J. C. Fox, R. E. Gilligan, A. K. Pitts, H. R. Bennett, M. J. Gaunt

Institution: University of Cambridge

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Swansea University, Engineering and Physical Sciences Research Council

Awards: G2492068546, G4729947956, G6418290443, Changing the nature of chemical synthesis through metal catalyzed C-H bond functionalization