Work

Dermal fibroblasts tumor suppression of ras-transformed keratinocytes is associated with induction of squamous cell differentiation.

Year: 1994

Type: article

Abstract: We have previously reported that tumor formation of ras-transformed keratinocytes can be suppressed by dermal fibroblasts through production of a diffusible growth inhibitory factor of the transforming growth factor-beta (TGF-beta) family. Keratinocytes transformed by ras and E1a oncogenes or papilloma-derived keratinocytes transformed by a ras oncogene show concomitant resistance to dermal fibroblast tumor suppression and TGF-beta growth inhibition. We report here that dermal fibroblast tumor suppression is associated with a striking induction of squamous cell differentiation and that this effect is blocked in tumors resistant to dermal fibroblast inhibition. This experimental system strongly supports the notion that suppression of tumorigenicity and induction of a differentiated phenotype are closely associated events.

Source: PubMed Central

Authors: S Ramón y Cajal, C Missero, E Marchetti, G P Dotto

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: Growth differentiation control in primary keratinocytes, Molecular Basis of Cancer Virus Replication, Transformation, and Innate Defense

OpenAlex ID: W228094307

FWCI: 0.106

Cites: 27

Cited by: 9

Related to: 10