Work

Possible Reactivation of Chromosomally Integrated Human Herpes Virus 6 (ciHHV-6) after Treatment with HDAC Inhibitor and Correlation of HHV-6 Viral Load with Host Chimerism after Allogeneic Stem Cell Transplantation in a ciHHV-6 Recipient

Year: 2016

Type: article

Abstract: Human Herpes Virus 6 (HHV-6) is an important opportunistic pathogen in Hematopoietic Stem cell transplant (HSCT) recipients. It is estimated that 1-2% of the population has chromosomally integrated HHV-6 (ciHHV-6). HHV-6 reactivation from ciHHV-6 state has been observed in vivo or in vitro and can be facilitated by certain drugs, including HDAC inhibitors. We cared for a 54 year old female with Flt3+ AML, who received second induction with Idarubicin, Cytarabine and Vorinostat and achieved complete remission.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2015.11.540

Authors: Ioannis Politikos, Malgorzata McMasters, Christine Bryke, David E. Avigan, Vassiliki A. Boussiotis

Institutions: Memorial Sloan Kettering Cancer Center, Beth Israel Deaconess Medical Center, Harvard University

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650