Work

From migration to settlement: the pathways, migration modes and dynamics of neurons in the developing brain

Year: 2016

Type: article

Abstract: Neuronal migration is crucial for the construction of the nervous system. To reach their correct destination, migrating neurons choose pathways using physical substrates and chemical cues of either diffusible or non-diffusible nature. Migrating neurons extend a leading and a trailing process. The leading process, which extends in the direction of migration, determines navigation, in particular when a neuron changes its direction of migration. While most neurons simply migrate radially, certain neurons switch their mode of migration between radial and tangential, with the latter allowing migration to destinations far from the neurons' site of generation. Consequently, neurons with distinct origins are intermingled, which results in intricate neuronal architectures and connectivities and provides an important basis for higher brain function. The trailing process, in contrast, contributes to the late stage of development by turning into the axon, thus contributing to the formation of neuronal circuits.

Source: Proceedings of the Japan Academy Series B

DOI: 10.2183/pjab.92.1

Authors: Yumiko HATANAKA, Yan ZHU, Makio TORIGOE, Yoshiaki KITA, Fujio MURAKAMI

Institutions: National Institute for Physiological Sciences, National Institute of Genetics, RIKEN, The University of Osaka

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: diamond

Funders: Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science

Awards: Mechanisms underlying intracortical distribution of inhibitory interneurons and their synaptic connections, A role of Plexin A2/A4 signaling in layer formation of the mouse cerebral cortex, Unravelling Mechanisms Underlying Termination of Neuronal Migration