Cholesterol lowering effects of bovine serum immunoglobulin in human participants with mild hypercholesterolemia
Year: 2006
Type: dissertation
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Hypercholesterolemia is a major risk factor for cardiovascular disease (CVD).\nInterestingly, the consumption of dairy products, namely milk, has been shown to lower\ncholesterol. The mechanism of action surrounding this observation has been attributed\nto the protein fraction of milk. While there have been many studies evaluating the\neffects of dietary protein sources on cholesterol concentrations, few studies have\nevaluated specific animal protein components and no human clinical studies regarding\nthe effects of animal plasma protein fractions on cholesterol metabolism have been\nconducted. This study examined the effect of an oral serum bovine immunoglobulin\nprotein fraction (bIg) derived from US Department of Agriculture approved beef (aged <\n30 months) on lipid indices in hypercholesterolemic humans.\nParticipants included men and women (aged 25 – 70 years) with mild\nhypercholesterolemia (5.44-6.99 mmol/L) who were not receiving cholesterol-lowering\nmedication. Treatment consisted of the randomized, double blind, parallel group,\nplacebo-controlled administration of 5 grams (g) bIg daily for 6 weeks (W) in 52\nparticipants (n = 26 each in treatment and control groups). Mean (± SD) baseline\ntreatment and placebo total cholesterol (TC) was 6.33 ± 0.1 mmol/L and 6.16 ± 0.1\nmmol/L respectively. A repeated-measures multivariate analysis of covariance (MANCOVA) covaried for change in total energy and alcohol intake, and a Tukey posthoc\nexamination of the data showed that the bIg-treated group demonstrated a\nsignificant reduction in TC at 3-week (W) (5.98 ± 0.5 mmol/L; P < 0.05) and 6-week (W)\n(5.97 ± 0.7 mmol/L; P > 0.05) intervals compared to baseline. The 6W concentration\nwas significantly lower than the placebo group (P < 0.05). Additionally, study findings\ndisplayed no significant changes in the placebo group or in any other lipid indexes or\nmarkers associated with hepatorenal or cardiovascular health. Consumption of bIg\nappears to lower major lipid indexes associated with CVD.
Author: Melinda Lori Black
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2282300994