Work

Home Sweet Home: a Foxl1+ Mesenchymal Niche for Intestinal Stem Cells

Year: 2016

Type: article

Abstract: The intestinal epithelium undergoes rapid and constant renewal accomplished by intestinal stem cells (ISCs) every 3–5 days. ISCs divide and give rise to highly proliferative transit-amplifying progenitor cells that differentiate into the multiple differentiated cell types present in the crypt and villus.1 ISCs reside in a microenvironment surrounded by epithelial and underlying mesenchymal cells within the lamina propria populated by multiple cell types. Over the past decade, considerable advances have shown that the ISC niche is composed of molecular mediators that act in a paracrine or autocrine manner to maintain proper ISC behavior marked by self-renewal and multipotency.

Source: Cellular and Molecular Gastroenterology and Hepatology

DOI: 10.1016/j.jcmgh.2016.01.004

Authors: Amanda T. Mah, Calvin J. Kuo

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Digestive system and related health

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,430

Funder: National Institute of Diabetes and Digestive and Kidney Diseases