Phase I Study of Brentuximab Vedotin for the Prevention of Acute GvHD after Unrelated Allogeneic Stem Cell Transplantation
Year: 2016
Type: article
Abstract: After exposure to allo-antigens, CD30 expression is induced on a distinct population of T cells that are predominantly proliferating and secreting IL-5 and IFN-γ. Blockade of the CD30/CD30L pathway in vivo results in reduced severity of GVHD mediated by CD4 T cells.(Blazar et al.) CD30 is up-regulated in murine regulatory T cells (Tregs) which are important in protecting the host against acute GVHD.(Zeiser et al.) In a mouse model, early blockade of CD30 signaling (< 4 days after transplant), but not late (> 4 days), led to increased GVHD.
Institutions: Washington University in St. Louis, The Ohio State University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2283439679