Work

IMPROVED SYNTHESIS OF SUBSTITUTED 2-ARYL-N- [2-(DIMETHYLAMINO)ETHYL]QUINOLIN-4-AMINES AND THEIR ACTIVITY AS ANTAGONISTS OF IMMUNOSTIMULATORY CpG-OLIGODEOXYNUCLEOTIDES

Year: 2007

Type: article

Abstract: A general methodology for the synthesis of substituted quinolin-4-amines developed by us previously has been simplified.The synthesized compounds, depending on substituents, show activities in the range from 35 nM to 550 nM as antagonists of immunostimulatory oligodeoxynucleotides containing a CpG motif.A SAR analysis is presented.

Source: Heterocyclic Communications

DOI: 10.1515/hc.2007.13.1.9

Authors: Ekaterina Paliakov,, Maged Henary,, Martial Say,, Lubomir Janda,, Lori Manzel†,, Donald E. Macfarlane†,, Lucjan Strekowski,

Institutions: Georgia State University, University of Iowa, Iowa City VA Medical Center

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $1,808

OpenAlex ID: W2284304490

FWCI:

Cites: 11

Cited by: 1

Related to: 10