Gender-specific differences in benefit and risk of preventive pharmacological treatment for coronary heart disease Systematic review of gender- and evidence based quality of drug interventions used in Germany
Year: 2007
Type: article
Study design: Systematic Review
Abstract: The objective of this systematic review was to develop criteria for gender sensitive research and to determine the gender specific evidence for drugs used in primary prevention of coronary heart disease in women. Gender related and EBM quality criteria for conducting clinical trials were collected and put together. The result was an instrument capable to detect gender bias as well as other systematic error that might flaw the results of clinical trials. The next step was a systematic literature search to retrieve trials studying the effects of drugs used in primary prevention of coronary heart disease. Trials were evaluated using the instrument constructed in step 1.Findings were much clearer for both genders when analyses was made gender specific. The treatment effects were more distinct in men whereas they could not be shown in women. When put together, the effect size was underestimated for men and overestimated for women. Conducting gender sensitive studies leads to a greater validity of the results for both, women and men.
Author: Müller, Veronika Elisabeth
Language: English
Topic: Sex and Gender in Healthcare
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2285289525