Work

Metal-responsive structural transformation between artificial DNA duplexes and three-way junctions

Year: 2016

Type: article

Abstract: complex, which served as a template for the 3WJ assembly. Altering the amount and identity of the metal ion regulated the 3WJ induction efficiency. Removal of the metal using EDTA quantitatively regenerated the duplexes. The metal-dependent structural conversion shown here has many potential applications in the development of stimuli-responsive DNA materials.

Source: Chemical Science

DOI: 10.1039/c6sc00383d

Authors: Yusuke Takezawa, Shuhei Yoneda, Jean-Louis H. A. Duprey, Takahiro Nakama, Mitsuhiko Shionoya

Institution: The University of Tokyo

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funder: Japan Society for the Promotion of Science

Awards: Development of DNA strand displacement reactions using bifacial nucleobases that form both hydrogen-bonded and metal-mediated base pairs, Creation of Supramolecular Complex Systems based on Dynamic Chemistry, Construction of PCR-like amplification system of artificial metallo-DNAs, Precise metal array methods using a template ranged from one atom to biomacromolecules