Associations of total and free 25OHD and 1,25(OH)2D with serum markers of inflammation in older men
Year: 2016
Type: article
Abstract: UNLABELLED: Vitamin D is hypothesized to suppress inflammation. We tested total and free vitamin D metabolites and their association with inflammatory markers. Interleukin-6 levels were lower with higher 25-hydroxyvitamin D. 1,25-dihydroxyvitamin D and free 25OHD associations mirrored those of 25OHD. However, associations for the two metabolites diverged for tumor necrosis factor alpha (TNF-α) soluble receptors. INTRODUCTION: Vitamin D is hypothesized to suppress inflammation, and circulating 25-hydroxyvitamin D (25OHD) and inflammatory markers are inversely correlated. However, total serum 25OHD may not be the best indicator of biologically active vitamin D. METHODS: We tested serum total 25OHD, total 1,25(OH)2D, vitamin D binding protein (DBP), and estimated free 25OHD and free 1,25(OH)2D associations with inflammatory markers serum interleukin-6 (IL-6), TNF-α and their soluble receptors, interleukin-10 (IL-10), and C-reactive protein (CRP) as continuous outcomes and the presence of ≥2 inflammatory markers in the highest quartile as a dichotomous outcome, in a random subcohort of 679 men in the Osteoporotic Fractures in Men (MrOS) study. RESULTS: IL-6 was lower in men with higher 25OHD (-0.23 μg/mL per standard deviation (SD) increase in 25OHD, 95 % confidence intervals (CI) -0.07 to -0.38 μg/mL) and with higher 1,25(OH)2D (-0.20 μg/mL, 95 % CI -0.0004 to -0.39 μg/mL); free D associations were slightly stronger. 25OHD and DBP, but not 1,25(OH)2D, were independently associated with IL-6. TNF-α soluble receptors were inversely associated with 1,25(OH)2D but positively associated with 25OHD, and each had independent effects. The strongest association with ≥2 inflammatory markers in the highest quartile was for free 1,25(OH)2D (odds ratios (OR) 0.70, 95 % CI 0.54 to 0.89 per SD increase in free 1,25(OH)2D). CONCLUSIONS: Associations of 1,25(OH)2D and free 25OHD with IL-6 mirrored those of 25OHD, suggesting that 1,25(OH)2D and free D do not improve upon 25OHD in population-based IL-6 studies. However, associations for the two metabolites diverged for TNF-α soluble receptor, warranting examination of both metabolites in studies of TNF-α and its antagonists.
Source: Osteoporosis International
Institutions: Oregon Health & Science University, University of California, Los Angeles, University of Birmingham, Universitair Ziekenhuis Leuven, KU Leuven, University of California, Davis, California Pacific Medical Center, Columbia University Irving Medical Center, Columbia University, University of California San Diego, University of Alabama at Birmingham, Stanford Medicine, Stanford University, University of Pittsburgh
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,090
Awards: Osteoporotic Fractures in Men (MrOS) - Minneapolis, Oregon Clinical and Translational Research Institute, Osteoporatic Fractures in Men (MrOS), G2929263391, G3132380459, G3204558959, UCLA Clinical and Translational Science Institute, G3396628412, Osteoporotic Fractures in Men (Mr. Os) Palo Alto, G4253755194, Osteoporotic Fractures in Men (MrOS) - Administrative Center, PITT-MCRC for Rheumatic and Musculoskeletal Diseases, G4712859843, G5281952516, Osteoporotic Fractures in Men (Mr.OS), Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating Center, G6986132784, Osteoporotic Fractures in Men (MrOS) - Portland, G7058527481, G7446983892, Osteoporotic Fractures in Men_MrOS Renewal_Birmingham, Immunobiology of Leprosy, Mineralization Gene Variants: Biochemical Implications and Associations with BMD, DBP and the bioavailability and function of vitamin D, G8511401681, G9000125773
OpenAlex ID: W2287262541