Work

Investigation into the effects and mechanisms of rapamycin treatment in two mouse models of Complex I-deficient neurological pathology

Year: 2014

Type: dissertation

Abstract: Treatments to stop or reverse the debilitating progression of early-and late-onset neurological diseases remain undiscovered.Collective evidence suggests that inhibition of the mechanistic target of rapamycin (mTOR) signaling pathway is effective at reducing markers of pathology in experimental models of age-related and developmental neurological diseases.These include, but are not limited to, models for Alzheimer's disease, Parkinson's disease, Huntington's disease, Fragile X syndrome, Tuberous Sclerosis Complex and Leigh syndrome.How regulation of mTOR activity

Source: ResearchWorks at the University of Washington (University of Washington)

Author: Melana E. Yanos

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2287911956

Cites: 238

Cited by:

Related to: 10