In Vivo and in Vitro Evaluation of the Inhibitory Effect of Some Medicinal Plant Extracts on Haemozoin Concentration
Year: 2016
Type: article
Abstract: The resistance of current drugs against malaria parasite is increasing, thus the need for evaluation of the haemozoin (HZ) concentration in malaria parasite as a novel strategy for malaria control. Haemozoin load in the blood of patients was measured after taking antimalarials or plants extracts. The tested plant extracts were established to reduce HZ concentration in vivo. Haemozoin was extracted from the blood samples of all the malaria positive patients studied by centrifugation and the concentration analyzed spectrophotometrically at 400 nm wavelength. Comparative anti-malaria activity of some conventional drugs: Maldox, Halfan, Artecxin, Amatem, Mefloquine (quinolines) and Malmed, the leaf and stem back extracts of Sarcocephalius latifolius and Alstonia boonei, containing potent pyhytochemicals including tannins, flavonoids, saponins, alkaloids, was evaluated to establish the most effective agent for haemozoin reduction and subsequently, malaria therapy. Each agent was administered to patients in each malaria episode, and the absorbance of haemozoin produced determined at 4000 nm wavelength. Packed cell volume (PCV) was estimated to establish the proportion of red blood cells
Institutions: University of Nigeria, Nnamdi Azikiwe University
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2288042941