Work

Impact of Co-Processing on Some Fundamental Physicochem

Year: 2013

Type: article

Abstract: The aim of this study was to evaluate the effect of co-processing of microcrystalline cellulose (MCC) with Eudragit L100 (R) , cellulose acetate phthalate and ethyl cellulose respectively on the compaction, flow and disintegration properties of MCC.Co-processing MCC with the different polymers enhanced the flow and disintegration properties of MCC as a direct compression excipient for tablets production.When evaluated with the Heckle model, there was no remarkable change in the packing characteristics of the modified motifs in relation to the unmodified; however there was a slight but variable decrease in dilution capacity.This study shows the potential attribute of co-processing MCC with other polymers.

Source: IOSR Journal of Pharmacy and Biological Sciences

DOI: 10.9790/3008-0525567

Author: Philip F. Builders

Institutions: Delta State University, National Institute for Pharmaceutical Research and Development

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: hybrid

OpenAlex ID: W2312200541

FWCI:

Cites: 38

Cited by: 2

Related to: 10