Work

Harnessing the IL-7/IL-7Rαaxis to improve tumor immunotherapy

Year: 2016

Type: article

Abstract: IL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8(+) T cells downregulate IL-7Rα, it is thought IL-15 is more important. However, we find that CD8(+) T cells activated with IL-12 have elevated IL-7Rα and rely on IL-7 for persistence and antitumor immunity.

Source: OncoImmunology

DOI: 10.1080/2162402x.2015.1122865

Authors: C. Bryce Johnson, John Wrangle, Shikhar Mehrotra, Zihai Li, Chrystal M. Paulos, David J. Cole, Charles D. Surh, Mark P. Rubinstein

Institutions: Medical University of South Carolina, Pohang University of Science and Technology, La Jolla Institute for Immunology, Institute for Basic Science

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913

Funder: National Cancer Institute

Award: G6832147345

OpenAlex ID: W2289188132

FWCI: 0.338

Cites: 10

Cited by: 3

Related to: 10