Pathogenesis and pathophysiology of COPD
Year: 2009
Type: article
Abstract: Chronic obstructive pulmonary disease (COPD) is a slowly progressed disease characterized by chronic irreversible airway obstruction with increased airway resistance and loss of elastic recoil by lung parenchymal destruction. COPD is a leading cause of morbidity and mortality worldwide. COPD is defined as a preventable and treatable disease with some significant extrapulmonary effects that may contribute to the severity in individual patients. Pathological changes characteristic of COPD are found in the proximal airways, peripheral airways, lung parenchyma, and pulmonary vasculature, showing chronic inflammation, and structural changes resulting from repeated injury and repair mostly caused by inhaled cigarette smoke. This pathological changes lead to airway trapping and progressive airway limitation. (Korean J Med 77:383-400, 2009)
Author: Chul Gyu Yoo
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $500
OpenAlex ID: W2289399234