Year: 2014
Type: dissertation
Study design: Observational Study
Abstract: Purpose: To examine the relationship between geographic atrophy (GA) progression and choroidal thickness (CT) and cataract surgery. Methods: Previously recorded Fundus Autofluorescence (FAF) and Spectral-DomainOptical Coherence Tomography (SD-OCT) images of patients with GA were analysed and GA area and choroidal thickness were measured in different moments in time.Subfoveal CT was measured in all eyes and in those with the largest lesion outside the fovea an additional measurement was made at the centre of the lesion.GA area progression and CT progression were calculated based in these measurements.The eyes were then divided in three groups according to their phakic status: pseudophakic, surgery performed during the study and phakic.Statistically significant differences between these groups in GA area progression were calculated.Differences in GA progression in the second group before and after surgery were also analysed.Results: Median and mean GA progression rates in the three groups were 0.05/0.10;0.13/0.13and 0.08/0.11mm2/month respectively (p=0.154).In the patients intervened during the study, mean GA progression rates before and after surgery were 0.09±0.12mm2/month and 0.08±0.06mm2/month respectively (p=0.874).We found no association between initial subfoveal CT or initial largest lesion CT and GA progression (p=0.139;p=0.910). Conclusion:We found no association between geographic atrophy progression and choroidal thickness or phakic or pseudophakic status.
DOI: 10.34626/8hmb-h028
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Wellcome Trust, Research Councils UK
OpenAlex ID: W2289449272