Effects of weaning on polymorphonuclear cells phagocytic activity, lymphocyte proliferation and serum IgA-concentration in foals
Year: 2008
Type: article
Abstract: SArwAr, A., V. BuddE, H. EnBErgS: Effects of weaning on PMn cells phagocytic activity, lymphocyte proliferation and serum IgA-concentration in foals.Vet.arhiv 78, 1-11, 2008. ABStrActEighty-four foals (46 females; 38 males) of different breeds (Thoroughbreds, Standardbred, German Warmbloods), aged 5-6 months, were used in this study to evaluate the effects of weaning and other influencing factors like gender, breed and serum cortisol content on polymorphonuclear cells (PMNC) phagocytic activity, mitogeninduced lymphocyte proliferation and serum IgA-concentration.PMN phagocytic activity was measured by the luminal-dependent chemiluminescence, lymphocyte proliferation rate by MTT-test and serum IgA-level by radial immunodiffusion.PMNC phagocytic activity ranged between 4500-6000 cpm/μL in weanling foals.Despite a slight increase in the beginning, PMNC phagocytic activity clearly declined (P<0.0) the next day to weaning and thereafter, rose again.Lymphocyte proliferation showed a marked rise after first day of the study and then remained unaltered until the end of study except for a minor depression following weaning.Weaning induced a slight but not significant rise in serum IgA-concentrations.Among other variables, breed had a major influence on PMNC phagocytic activity and serum IgA-concentration.This may be a real influence of breed or one of stud farm/management.Interestingly, serum cortisol content did not show a correlation with any of the parameters studied.It is conceivable that weaning has a suppressive effect on the phagocytic activity of PMNC.
Authors: Sarwar, Anas, Budde, Verena, Enbergs, Heinrich
Institutions: University of Agriculture Faisalabad, University of Bonn
Language: English
Topic: Animal health and immunology
Subfield: Animal Science and Zoology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2289953656