Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections
Year: 2016
Type: review
Abstract: Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation during chronic infection of the cystic fibrosis (CF) lung, including reduced production of virulence factors, transition to a biofilm-associated lifestyle, and evolution of high-level antibiotic resistance. Populations of P. aeruginosa in chronic CF lung infections typically exhibit high phenotypic diversity, including for clinically important traits such as antibiotic resistance and toxin production, and this diversity is dynamic over time, making accurate diagnosis and treatment challenging. Population genomics studies reveal extensive genetic diversity within patients, including for transmissible strains the coexistence of highly divergent lineages acquired by patient-to-patient transmission. The inherent spatial structure and spatial heterogeneity of selection in the CF lung appears to play a key role in driving P. aeruginosa diversification.
Source: Trends in Microbiology
Institutions: University of Liverpool, University of York
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,753
Funder: Wellcome Trust
Awards: Institutional Strategic Support Fund Phase2 FY2014/16, Genetic diversification and within-host evolution of chronic Pseudomonas aeruginosa infections in cystic fibrosis patients., Understanding the role of temperate bacteriophages in the ecology and evolution of Pseudomonas aeruginosa in the cystic fibrosis lung environment.
OpenAlex ID: W2290216457