Year: 2013
Type: article
Abstract: The aim of the study was to describe the urinary electrophoretic pattern of dogs with heartworm disease. \nUrine samples from 15 heartworm-infected and 15 healthy dogs were taken. Urinary specific gravity, urinary \nprotein concentration and the urine protein/creatinine (U P/C) ratio were determined. Urine proteins were \nfractionated using SDS-PAGE. Results showed statistically significant differences for the U P/C ratio \n(P<0.05) but not for USG and urinary protein concentrations (P>0.05) between groups. Urinary protein SDSPAGE analysis showed eight distinct bands in the urine of heartworm-infected dogs. The presence of proteins exclusively found in the urine of infected dogs suggests renal damage, even in cases of light proteinuria, indicating that SDS-PAGE is a sensitive method for the identification and characterisation of renal \nproteinuria in dogs with heartworm disease.
Authors: Diana M. Beristain-Ruiz, Elena Carretón, Carlos Arturo Rodríguez-Alarcón, José Alberto Montoya-Alonso, Rafael Morales‐Barrera
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1535302690