Work

Selenoprotein P in colitis-associated carcinoma

Year: 2015

Type: article

Abstract: Patients with inflammatory bowel disease are often deficient in micronutrients such as selenium and have an increased risk of colon cancer. We tested whether the selenium transport protein, selenoprotein P, could modify colitis-associated cancer. Our results indicate that global SEPP1 haploinsufficiency augments tumorigenesis and mediates oxidative damage in the intestine.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2015.1075094

Authors: Sarah P. Short, Caitlyn Whitten-Barrett, Christopher S. Williams

Institutions: Vanderbilt University, Vanderbilt-Ingram Cancer Center, VA Tennessee Valley Healthcare System

Language: English

Topic: Selenium in Biological Systems

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Crohn's and Colitis Foundation of America, Crohn's and Colitis Foundation, National Institute of Diabetes and Digestive and Kidney Diseases