Year: 2015
Type: review
Abstract: Advancements in molecular biology have led to a greater understanding of the individual proteins responsible for generating cerebral edema. In large part, the study of cerebral edema is the study of maladaptive ion transport. Following acute CNS injury, cells of the neurovascular unit, particularly brain endothelial cells and astrocytes, undergo a program of pre- and post-transcriptional changes in the activity of ion channels and transporters. These changes can result in maladaptive ion transport and the generation of abnormal osmotic forces that, ultimately, manifest as cerebral edema. This review discusses past models and current knowledge regarding the molecular and cellular pathophysiology of cerebral edema.
Institution: University of Maryland, Baltimore
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
Awards: Role of TRP channels in secondary injury after brain trauma, Astrocyte regulation of the blood-brain barrier in intracerebral hemorrhage, TrpM4 channel in spinal cord injury, Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channel, Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subara
OpenAlex ID: W2291424342