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Flexible Octopus‐Shaped Hydrogel Particles for Specific Cell Capture

Year: 2016

Type: article

Abstract: Multiarm hydrogel microparticles with varying geometry are fabricated to specifically capture cells expressing epithelial cell adhesion molecule. Results show that particle shape influences cell-capture efficiency due to differences in surface area, hydrodynamic effects, and steric constraints. These findings can lead to improved particle design for cell separation and diagnostic applications.

Source: Small

DOI: 10.1002/smll.201600163

Authors: Lynna Chen, Harry Z. An, Ramin Haghgooie, Aaron T. Shank, Joseph M. Martel, Mehmet Toner, Patrick S. Doyle

Institutions: Massachusetts Institute of Technology, Harvard University, Massachusetts General Hospital

Language: English

Topic: Microfluidic and Bio-sensing Technologies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of Biomedical Imaging and Bioengineering, Institute for Collaborative Biotechnologies

Awards: G226397104, Bio-MicroElectroMechanical Systems (BioMEMS) Resource Center

OpenAlex ID: W2291520141

FWCI: 2.435

Cites: 62

Cited by: 40

Related to: 10