Work

The “π‐Clamp” Offers a New Strategy for Site‐Selective Protein Modification

Year: 2016

Type: article

Abstract: Pentelute and co-workers have identified a small encodable cysteine-containing peptide sequence that allows selective modification with perfluoroaryl probes. This π-clamp requires no external catalyst and is not limited to certain positions within a protein.

Source: ChemBioChem

DOI: 10.1002/cbic.201600106

Authors: Jeffery M. Tharp, Wenshe R. Liu

Institution: Texas A&M University

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Cancer Institute

Award: Phage Display with Two Genetically Incorporated Noncanonical Amino Acids