Year: 2012
Type: dissertation
Study design: Observational Study
Abstract: The COMT val 158 variant has been associated with impaired cognitive function compared to the met 158 variant yet gene-gene interactions are not well described.In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the α2b-adrenergic receptor on episodic memory performance.Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val 158 carriers compared to met 158 carriers.
Author: Kris Naudts
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2291641813
