Resting heart rate as a low tech predictor of coronary events in women: prospective cohort study
Year: 2009
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To evaluate resting heart rate as an independent predictor of cardiovascular risk in women. DESIGN: Prospective cohort study. SETTING: The Women's Health Initiative was undertaken at 40 research clinics in the United States. PARTICIPANTS: 129 135 postmenopausal women. MAIN OUTCOME MEASURE: Clinical cardiovascular events. RESULTS: During a mean of 7.8 (SD 1.6) years of follow up, 2281 women were identified with myocardial infarction or coronary death and 1877 with stroke. We evaluated associations between resting heart rate and cardiovascular events in Cox regression models adjusted for multiple covariates. Higher resting heart rate was independently associated with coronary events (hazard ratio 1.26, 95% confidence interval 1.11 to 1.42 for highest [>76 beats per minute] v lowest quintile [<or=62 beats per minute]; P=0.001), but not with stroke. The relation between heart rate and coronary events did not differ between white women and women from other ethnic groups (P for interaction=0.45) or between women with and without diabetes (P for interaction=0.31), but it was stronger in women aged 50-64 at baseline than in those aged 65-79 (P for interaction=0.009). CONCLUSION: Resting heart rate, a low tech and inexpensive measure of autonomic tone, independently predicts myocardial infarction or coronary death, but not stroke, in women. TRIAL REGISTRATION: ClinicalTrials.gov NCT00000611.
Source: BMJ
DOI: 10.1136/bmj.b219
Institutions: AstraZeneca (United Kingdom), George Washington University, Fred Hutch Cancer Center, University of Massachusetts Chan Medical School, University of Wisconsin–Madison, Brigham and Women's Hospital, Harvard University, University of California San Diego, Women's Health Initiative, AstraZeneca (United States), Detroit Medical Center, University of Iowa
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funder: National Institutes of Health
Awards: CLIN CTR FOR THE CLIN TRIAL & OBSERVATIONAL STUDY OF WHI, Women's Health Initiative, Women's Health Initiative, Women's Health Initiative, G1286168924, Women's Health Initiative, Women's Health Initiative, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, Women's Health Initiative, G152626716, Women's Health Initiative, G1623571357, Women's Health Initiative, Women's Health Initiative, G181468914, Women's Health Initiative, G211028185, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, Women's Health Initiative, G2182082016, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, Women's Health Initiative, G2768409618, G300426088, G3053443584, G306350359, G3290335435, Women's Health Initiative, G3337978133, Women's Health Initiative Memory Study (WHIMS), G3404453056, Women's Health Initiative, G3658685098, G3696348274, G3916577102, Women's Health Initiative, G4002295999, Women's Health Initiative, Women's Health Initiative, G413560588, COORDINATING CENTER FOR WOMEN'S HEALTH INITIATIVE, G429396632, G4355687608, G445374210, Women's Health Initiative, Women's Health Initiative, Women's Health Initiative, Women's Health Initiative, G5238945333, FOR ALL FIELD CENTER FOR WHI EXTENSION, Women's Health Initiative, G5415877130, Women's Health Initiative, G5611709376, Women's Health Initiative, G5959015892, G5965015984, G6424558485, G6522987136, G6730395537, Women's Health Initiative, Women's Health Initiative, Women's Health Initiative, G6893458194, Women's Health Initiative, G7223985928, Women's Health Initiative, G7422186829, Women's Health Initiative, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, G7572166205, G7582705761, G7739768352, Women's Health Initiative, CLINICAL CENTER FOR THE CLINICAL TRIAL & OBSERVATIONAL STUDY OF WHI, G8226798419, G857724489, G8606667874, G8898275213, G8913509553, Women's Health Initiative, G985928507
OpenAlex ID: W1974163026