Work

c-kit + Cardiac Stem Cells

Year: 2016

Type: article

Abstract: One of the lingering controversies in the field of cardiac regenerative medicine has been around the origin of c-kit+ cardiac stem cells in the heart and their contribution towards cardiac homeostasis. A recent study reports that a subpopulation of c-kit+ cardiac progenitors emerges from the cardiac neural crest (CNC) with the capacity to give rise to cardiomyocytes. Contribution of CNC derived c-kit+ cells to cardiac myocyte development is regulated by bone morphogenetic protein (BMP). However, ex vivo manipulation of CNC(c-)(kit) cells reveals efficient transformation to early cardiac progenitors.

Source: Circulation Research

DOI: 10.1161/circresaha.115.308103

Authors: Mohsin Khan, Walter J. Koch

Institution: Temple University

Language: French

Topic: Congenital heart defects research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Heart, Lung, and Blood Institute