Relations between surgical variables, pulmonary regurgitation, right ventricular function, autonomic heart rate control and QRS duration in adolescents with repaired tetralogy of Fallot
Year: 2008
Type: dissertation
Study design: Observational Study
Abstract: and Keywords\nBackground:\nPatients with repaired Tetralogy of Fallot have increased risk of arrhythmias, correlating with prolongation of the QRS complex. The underlying mechanisms are uncertain. We explored the relations between different surgical variables, pulmonary regurgitation, right ventricular function, autonomic heart rate control and QRS-duration in adolescents with repaired Tetralogy of Fallot.\n\nMethods and Results:\n17 patients (13-18 years) with repaired Tetralogy of Fallot underwent clinical examination, electrocardiogram, echocardiography, exercise testing, testing of autonomic heart rate control and cardiac magnetic resonance imaging. Details of previous surgical procedures were obtained from patients records. All variables were subjected to multivariate linear regression analyses.\nPatients operated with a transannular patch had larger pulmonary regurgitation fraction (r=18.82 (1.18;36.46), p=0.038). Pulmonary regurgitation was associated with increased right ventricular end diastolic volume (r=1.37 (0.86;1.88), p<0.000), which in turn was related to longer QRS-duration (r=0.40 (0.11;0.70), p=0.011). No other significant interrelations were found. \n\nConclusion:\nThe use of a transannular patch was the only surgical variable associated with pulmonary regurgitation in our study, in turn leading to right ventricular dilatation and prolongation of the QRS complex.
Author: Ingvild Billehaug Norum
Institution: University of Oslo
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2292164272