Work

Effects of Erythroid Hyperplasia on Patterns of Glycin-2-C14 Uptake in Heme and Globin of Human Peripheral Blood in Vivo

Year: 1966

Type: article

Abstract: The rate of appearance of C14 in the heme and globin of peripheral blood following intravenous administration of glycine-2-C14 has been measured in normals and in patients with androgen-induced erythrocytosis, polycythemia vera (iron deficiency) and virilizing Cushing’s disease with polycythemia. In all these cases of accelerated erythropoiesis a common alteration of the globin specific activity curve was observed. Heme specific activity curves were not affected. The changes in the globin specific activity curves are best explained by consideration of the marrow erythroid cellularity during erythrocytosis.

Source: Blood

DOI: 10.1182/blood.v28.3.303.303

Authors: DAVID G. NATHAN, FRANK H. GARDNER, Virginia B. Lemire

Institution: Harvard University

Language: English

Topic: Myeloproliferative Neoplasms: Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2292166084