Work

Elevated expression of HIF-lα in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia

Year: 2016

Type: article

Abstract: // Fei Wu 1,2,* , Sentai Ding 1,* , Xin Li 1 , Hui Wang 3 , Shuai Liu 1 , Haihu Wu 1 , Dongbin Bi 1 , Kejia Ding 1 and Jiaju Lu 1 1 Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China 2 Department of Urology, Huashan Hospital, Fudan University, Shanghai, China 3 Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China * These authors have contributed equally to this work Correspondence to: Jiaju Lu, email: // Keywords : benign prostatic hyperplasia(BPH), hypoxia inducible factor-1alpha(HIF-lα), acute urine retention(AUR), fetal prostate(FP), Pathology Section Received : September 23, 2015 Accepted : January 31, 2016 Published : February 23, 2016 Abstract Background: Benign prostatic hyperplasia (BPH) is one of the most common diseases in middle-age or older men. Increasing evidence has shown that BPH is associated with hypoxia microenvironment. Methods: We retrospectively collected patient data and tissue samples from fetal prostates(FP), normal prostates(NP), intra-acinar of BPH, peri-acinar of BPH, prostate cancers and sarcomas of prostate. The expression of HIF-1α, as well as VEGF was visualized by immunohistochemistry and statistically analyzed with clinical parameters. Results: Expression of HIF-lα was observed in intra-acinar of BPH (69.5%), prostate cancer (85.7%) and all FPs, while NP and peri-acinar of BPH tissues were all stained negative. HIF-lα levels in FPs and the malignant tumors were higher than BPH tissues( p < 0.05), and the expression of HIF-lα in intra-acinar of BPH was higher than NP and peri-acinar of BPH ( p < 0.05). The expression of HIF-lα was correlated with the weight of intra-acinar of prostate ( p < 0.05). And patients with prostate weight larger that 72.45g were prone to have HIF-lα moderate-positive expression, according to the ROC curve (AUC = 0.734, 95%CI = 0.630-0.838). Moreover, the risk of acute urine retention (AUR) for HIF-lα moderate-positive patients increased significantly (OR=5.517, 95%CI = 2.434-12.504). Conclusions: HIF-lα expression is increased in highly proliferative prostate tissues and correlated with the weight of intra-acinar prostate. Moreover, HIF-lα is also an independent risk factor for AUR occurrence in BPH patients.

Source: Oncotarget

DOI: 10.18632/oncotarget.7641