Work

Histone variant H2A.Z.2: A novel driver of melanoma progression

Year: 2015

Type: article

Abstract: Histone variants are attracting attention in the field of cancer epigenetics. Our study has established a novel role for the uncharacterized histone variant H2A.Z.2 as a driver of malignant melanoma. H2A.Z.2 promotes cellular proliferation by recruiting BRD2 and E2F1 to E2F target genes and facilitating their transcription. High H2A.Z.2 expression correlates with poor survival in patients, and its depletion sensitizes cells to chemotherapy and targeted therapies.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2015.1073417

Authors: Chiara Vardabasso, Sandra B. Hake, Emily Bernstein

Institutions: Icahn School of Medicine at Mount Sinai, Center for Integrated Protein Science Munich, Adolf-Butenandt-Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie, Ludwig-Maximilians-Universität München

Language: English

Topic: Chromatin Remodeling and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2292766924

FWCI: 0.516

Cites: 10

Cited by: 21

Related to: 10