Preexisting mild sleep disturbance as a vulnerability factor for inflammation-induced depressed mood: a human experimental study
Year: 2016
Type: article
Study design: Clinical Trial
Abstract: Sleep disturbance and depression are common, particularly in females, and sleep disturbance is a well-known risk factor for depression. Systemic inflammation has been suggested as a potential mechanism of this association. This study examined whether preexisting sleep disturbance acted as a vulnerability factor for depressed mood induced by an inflammatory challenge in healthy females vs males. In a randomized double-blind placebo-controlled design, volunteers aged 18-50 (N = 111; 67 females) were assigned to placebo or low-dose endotoxin. Before substance administration, sleep disturbance was assessed using the Pittsburgh Sleep Quality Index and dichotomized using median split (⩾ 3 vs < 3). Self-reported depressed mood (profile of mood states) and circulating proinflammatory cytokines (interleukin-6, tumor necrosis factor-α) were repeatedly assessed over 6 h. Among females, moderation of depressed mood by sleep disturbance was significant even after adjustment for covariates (X(2) = 12.73, df = 6, P < 0.05). There was a robust time-by-condition interaction in females with sleep disturbance (X(2) = 26.22, df = 6, P < 0.001), but not in females without sleep disturbance (X(2) = 8.65, df = 6, P = 0.19). Although cytokines increased equally in all females, the correlations between cytokines and depressed mood were significantly stronger in females with sleep disturbance. Among males, no moderating effect of sleep disturbance was observed. Inflammation-induced depressed mood was considerably more severe among females reporting mild sleep disturbance compared with those reporting no sleep disturbance, suggesting that even mild sleep disturbance may increase vulnerability for inflammation-induced depression in females. Furthermore, sleep disturbance appears to increase the vulnerability to depression by augmenting affective sensitivity to cytokines rather than by enhancing cytokine responses to inflammatory challenge in females.
Source: Translational Psychiatry
DOI: 10.1038/tp.2016.23
Authors: H J Cho, N I Eisenberger, R Olmstead, E C Breen, M R Irwin
Institution: University of California, Los Angeles
Language: English
Subfield: Biological Psychiatry
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,290
Funders: Brain and Behavior Research Foundation, National Alliance for Research on Schizophrenia and Depression, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Cancer Institute, NIH Clinical Center, National Center for Advancing Translational Sciences, Clinical and Translational Science Institute, University of California, Los Angeles
Awards: G1120375403, G1545794908, Aging: Sleep and Inflammatory Mechanisms in Depression Prevention, Social Isolation and Sleep Disturance in Aging: Inflammatory Mechanisms, Sleep, Inflamation, and Depression Occurrence in Breast Cancer Survivors, G2705997113, G2825077807, UCLA Clinical and Translational Science Institute, Sleep loss as a vulnerability factor for inflammation induced depressive symptoms in older women, UCLA Older Americans Independence Center, UCLA Clinical and Translational Science Institute, Inflammation-Induced Depressed Mood: The Role of Social Neurocognitive Mechanisms, Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune Mechanisms, Mechanisms of Sleep Disruption Hyperalgesia, Chronic Moderate Sleep Restriction in Older Long and Older Average Sleepers
OpenAlex ID: W2293103284