Year: 2015
Type: article
Abstract: Mutant RAS-driven cancer cells cope with proliferative stress by increasing basal autophagy to maintain protein/organelle and energy homeostasis. We recently demonstrated that casein kinase 1 alpha (CK1α), a therapeutically tractable enzyme, is critical for fine-tuning the transcriptional regulation of mutant RAS-induced autophagy and the development of mutant RAS-driven cancers.
Source: Molecular & Cellular Oncology
Authors: Jit Kong Cheong, David M. Virshup
Institution: Duke-NUS Medical School
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G3400911301, G5685068328
OpenAlex ID: W2293148989