Work

A nuclear targeted dual-photosensitizer for drug-resistant cancer therapy with NIR activated multiple ROS

Year: 2016

Type: article

Abstract: A nuclear targeted dual-photosensitizer was developed for photodynamic therapy against multidrug resistant cancer. Multiple reactive oxygen species (ROS) could be generated in the nucleus to directly break DNA double strands with a single 980 nm NIR laser irradiation, regardless of drug resistance.

Source: Chemical Science

DOI: 10.1039/c6sc00737f

Authors: Zhengze Yu, Wei Pan, Na Li, Bo Tang

Institution: Shandong Normal University

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, National Key Research and Development Program of China