Year: 2009
Type: article
Abstract: also severely reduced in TM-5a overexpressing osteoclasts.These results indicate that TM-5a/5b plays an important role in regulating actin adhesion structures of osteoclasts, most likely by stabilizing the actin microfilaments present in podosomes and the sealing zone.Therefore, the alternately spliced exons that form the N-termini and upstream sequences in the alpha gene mediate differential patterns of expression, subcellular location, and function in osteoclasts.
Author: Preeyal Kotadiya
Institution: The Ohio State University
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2293843906