Work

A Cytotoxic Principle of Tamarindus indica, Di-w-butyl Malate and the Structure-Activity Relationship of Its Analogues

Year: 1996

Type: article

Abstract: Bioassay-guided fractionation of the methanolic extract of Tamarindus indica fruits led to the isolation of L-(-)-di-n-butyl malate which exhibited a pronounced cytotoxic activity against sea urchin embryo cells. In order to study structure-activity relationships, close-structure relatives of di-n-butyl malate were synthesized using D-(+)- and L-(-)-malic acid as starting materials, and their cytotoxic activities were examined for the sea urchin embryo assay. L-(-)-Di-n-pentyl malate was the most effective inhibitor to the development of the fertilized eggs. Significant inhibitory activity was not seen in the esters of D-(-)-isomer.

Source: Zeitschrift für Naturforschung C

DOI: 10.1515/znc-1996-3-415

Authors: Akio Kobayashi, Mohd Ilham Adenarr, Shin-ichiro Kajiyama, Hiroshi Kanzaki, Kazuyoshi Kawazu

Institutions: The University of Osaka, Okayama University

Language: English

Topic: Phytochemical Studies and Bioactivities

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $2,712

Funder: Japan Society for the Promotion of Science